Incretin Analogues

The name describes a structural family: the molecules share recognisable sequence motifs with the natural hormones, are substituted at individual positions and, in several cases, carry a fatty-acid side chain. Describing a molecule as a single, dual or triple agonist is a classification by receptor profile, nothing more.

The category also lists the amylin analogue Cagrilintide. It is derived not from an incretin but from the pancreatic hormone amylin and addresses amylin and calcitonin receptors; its structure and analytics are covered in the guide to cagrilintide.

Listed in this category is GLP-3, a 39-amino-acid peptide with an agonist profile at the GIP, GLP-1 and glucagon receptors, hence the triple-agonist label. Background on its structure, naming and analytics is given in the guide to GLP-3.

The material is supplied as a lyophilised powder in a sealed vial. Incoming goods are recorded with their delivery date and storage location, so that a vial can be matched to the documentation that belongs to it. The material is tested at regular intervals by an external, independent laboratory, using HPLC for purity and mass spectrometry for identity, along with heavy-metal and endotoxin testing. The certificates that are available are published in the lab area, each naming the tested product, the method and the test date; material without a published certificate is marked as pending. The individual figures are explained in the guide to reading a certificate of analysis.

The sealed vial is kept cool, dry and protected from light; the notes are collected under storing lyophilised peptides. Dispatch is from Germany within the EU, securely packed.

All items in this category are research chemicals for in-vitro use only. They are not medicinal products, food or cosmetics and are not intended for use in or on humans or animals.